Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934

• Veronika Ulrich,
• Clara Brieke and
• Max J. Cryle

Beilstein J. Org. Chem. 2016, 12, 2849–2864, doi:10.3762/bjoc.12.284

• of under 2.0 Å (Table 3). Other P450 enzymes with high structural similarity to StaF are those from secondary metabolism and involve oxidative functionalisation of large substrates, such as pravastatin (CYP105AS, PDB ID: 4OQS) [42], oleandomycin (OleP, PDB ID: 4XE3) [43], mycinamicin (MycG, PDB ID

One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates

• Joshua P. Barham,
• Matthew P. John and
• John A. Murphy

Beilstein J. Org. Chem. 2014, 10, 2981–2988, doi:10.3762/bjoc.10.316

• 10.3762/bjoc.10.316 Abstract Nucleophilic trapping of iminium salts generated via oxidative functionalisation of tertiary amines is well established with stabilised carbon nucleophiles. The few reports of organometallic additions have limited scope of substrate and organometallic nucleophile. We report a

• . Keywords: iminium salt; organometallic; oxidative functionalisation; photoredox catalysis; tetrahydroisoquinoline; Introduction Tetrahydroisoquinolines (THIQs) are structural motifs prominent within biologically active natural products and pharmaceutical compounds [1][2]. From (−)-carnegine (1, a

• construct THIQs using green technologies, in mild conditions and with high atom efficiencies. Catalytic oxidative functionalisation of the C–H bond α- to the amine function is one such methodology. Iminium salts generated in this way can be intercepted by a nucleophile in a one-pot reaction (Scheme 1